Medical Journals

Been There, Not Done That — Melanoma in the Age of Molecular Therapy. NEJM 2011 (NEJMe1105792)

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. NEJM 2011 (NEJMoa1103782)

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma. NEJM 2011 (NEJMoa1104621)

Boceprevir for Untreated Chronic HCV Genotype 1 Infection. NEJM 2011 (NEJMoa1010494)

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection. NEJM 2011 (NEJMoa1009482)

Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection. NEJM 2009 (NEJMoa0807650)

Telaprevir for Previously Treated Chronic HCV Infection. NEJM 2011 (NEJMoa0908014)

Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer. NEJM 2009 (10.1056/NEJMoa0809003)
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis. NEJM 2009 (10.1056/NEJMoa0809493)
Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma. NEJM 2009;361:947-957.
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. NEJM 2009;361:958-967.
Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer. Gastroenterology 2009;137:1102-1113.
Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy. JAMA 2009;302:849-857.
Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes. NEJM 2009 (10.1056/NEJMoa0904327)
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance; for African-Americans, Hispanics, East Asians. Nature 2009 doi:10.1038/nature08309
Peginterferon Alfa-2b or Alfa-2a with Ribavirin for Treatment of Hepatitis C Infection. NEJM 2009 (10.1056/NEJMoa0808010)
Decline in Male Sexual Desire, Function, and Satisfaction During and After Antiviral Therapy for Chronic Hepatitis C. Gastroenterology 2009;137:873-884.
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma. NEJM 2009 (10.1056/NEJMoa0905360)
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009 doi:10.1016/S0140-6736(09)61525-7
Haemopoietic stem-cell transplantation with antibody-based minimal-intensity conditioning: a phase 1/2 study. Lancet 2009 doi:10.1016/S0140-6736(09)60945-4
Comparison of intravenous alteplase with a combined intravenous—endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. Lancet 2009 doi:10.1016/S1474-4422(09)70182-6
Zoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet doi:10.1016/S0140-6736(09)60250-6

Internal Medicine (more)

Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients. NEJM 2008;359:2417-2428.
Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study. BMJ doi:10.1136/bmj.a2642
Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease. JAMA 2008;300:2407-2416.
Thrombolytic Therapy and Mortality in Patients With Acute Pulmonary Embolism. Arch Intern Med 2008;168:2183-2190.
Comparative Effectiveness of Different β-Adrenergic Antagonists on Mortality Among Adults With Heart Failure in Clinical Practice. Arch Intern Med 2008;168(22):2415-2421.
Clinical Effectiveness of Beta-Blockers in Heart Failure. J Am Coll Cardiol 2009;53:184-192.
Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics. Circulation 2009;119:53-61.
Genetic Determinants of Response to Clopidogrel and Cardiovascular Events. NEJM 10.1056/NEJMoa0808227
Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon. NEJM 2008;359:2429-2441.
Peginterferon Alfa-2a and Ribavirin in Latino and Non-Latino Whites with Hepatitis C. NEJM 2009;360:257-267.
Analysis of CD8+ T-Cell–Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model. Gastroenterology 2009;136:1391-1401.
Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival. NEJM 2009;360:1815-1826.
Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet doi:10.1016/S0140-6736(09)60612-7

Oncology (more)

Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol doi:10.1016/S1470-2045(09)70002-6
Fluorouracil, Leucovorin, and Oxaliplatin With and Without Cetuximab in the First-Line Treatment of Metastatic Colorectal Cancer. J Clin Oncol DOI:10.1200/JCO.2008.20.8397.
A Randomized Phase IIIB Trial of Chemotherapy, Bevacizumab, and Panitumumab Compared With Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer. J Clin Oncol DOI:10.1200/JCO.2008.19.8135.
Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease. Gastroenterology 2009;136:138-148.
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol doi:10.1016/S1470-2045(08)70285-7
Sorafenib in Hepatocellular Carcinoma: Separating the Hype From the Hope. J Clin Oncol DOI:10.1200/JCO.2008.19.7996
Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia. NEJM 10.1056/NEJMoa0808253
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol doi:10.1016/S1470-2045(08)70339-5
Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet doi:10.1016/S0140-6736(08)61815-2
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I—II study. Lancet Oncol doi:10.1016/S1470-2045(09)70074-9
Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2. NEJM 2009;361:358-367.
Phase III Study of Gemcitabine Plus Docetaxel Compared With Capecitabine Plus Docetaxel for Anthracycline-Pretreated Patients With Metastatic Breast Cancer. J Clin Oncol 10.1200/JCO.2007.15.8485

Neurology (more)

Effect of urgent treatment for transient ischaemic attack and minor stroke on disability and hospital costs (EXPRESS study): a prospective population-based sequential comparison. Lancet Neurol doi:10.1016/S1474-4422(09)70019-5
Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol doi:10.1016/S1474-4422(09)70017-1
Epilepsy and Cognitive Impairments in Alzheimer Disease. Arch Neurol doi:10.1001/archneurol.2009.15
Different Patterns of Cerebral Injury in Dementia With or Without Diabetes. Arch Neurol doi:10.1001/archneurol.2008.579
Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. Lancet Neurol doi:10.1016/S1474-4422(08)70263-1
Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. The Lancet doi:10.1016/S0140-6736(08)61626-8.
Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol doi:10.1016/S1474-4422(08)70260-6.
Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis. Arch Neurol doi:10.1001/archneur.66.1.noc80047
Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab. Arch Neurol doi:10.1001/archneur.65.12.noc80051
Genomewide Association Studies of Stroke. NEJM 10.1056/NEJMoa0900094
Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study. Lancet Neurol doi:10.1016/S1474-4422(09)70081-X

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